The potential use of riluzole in câncer treatment
systematic review
DOI:
https://doi.org/10.24302/sma.v12.4293Abstract
Riluzole is a medication that has been used in the treatment of amyotrophic lateral sclerosis (ALS). Experimental studies have shown inhibitory effects on tumor growth with its administration. The aim of this systematic review was to analyze the potential of the treatment of canceres with the use of riluzole. The databases Web of Science, Scopus and PubMed were screened for published studies between 2007 and 2021 using the keywords cancer and riluzole. In the discussion section not only the relation between glutamate and cancer is examined but also how riluzole acts as an important signaling inhibitor of this component in regard to the growth rate and invasiveness of specific types of cancer. Most of the studies in vitro, in vivo and in humans report that riluzole has presented itself as a promising medication in the treatment of specific types of cancer. However, further researches are made necessary before making definite conclusions on the use of this drug in such cases.
Keywords: Neoplasms; Riluzole.
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